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Esomeprazole decreases the amount of acid produced in the stomach.

You should not use AcipHex if you are allergic to rabeprazole or to similar medicines such as lansoprazole (Prevacid), esomeprazole (Nexium), omeprazole (Prilosec, Zegerid), or pantoprazole (Protonix).

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Atrophic gastritis has been observed occasionally in gastric corpus biopsies from patients treated long-term with pantoprazole, particularly in patients who were Helicobacter pylori positive.


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These are not considered serious adverse reactions, and a pharmacist can recommend an over-the-counter analgesic such as acetaminophen or ibuprofen to help alleviate pain.

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Oral: 40 mg orally once a day, for short-term administration (up to 8 weeks); however an additional 8 weeks may be considered for patients who have not healed after the initial treatment.

The end point of symptom relief can be more difficult to obtain when compared with achieving mucosal healing in GERD and second doses of a PPI or longer treatment duration may be needed in these cases.

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Administration of PROTONIX Delayed-Release Tablets with food may delay its absorption up to 2 hours or longer; however, the C max and the extent of pantoprazole absorption (AUC) are not altered.

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Several mechanisms may explain the superior efficacy of rabeprazole on increasing intragastric pH and decreasing acid output on the first day of therapy.

Subjects who have had treatment with any investigational drug within the past 30 days.

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Fasting serum gastrin levels were assessed in two double-blind studies of the acute healing of erosive esophagitis (EE) in which 682 patients with gastroesophageal reflux disease (GERD) received 10 mg, 20 mg, or 40 mg of pantoprazole for up to 8 weeks.

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Esomeprazole (Nexium); Lansoprazole (Prevacid); Omeprazole (Prilosec); Pantoprazole ( Protonix); Rabeprazole (Aciphex).

It is used to treat erosive esophagitis or "heartburn" caused by (), a condition where the acid in the stomach washes back up into the esophagus.

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As a result of their acid dissociation constant (pKa) levels, they accumulate in the secretory canaliculus of the parietal cell, achieving higher concentrations here when compared with plasma.

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Because these pediatric trials had no placebo, active comparator, or evidence of a dose response, the trials were inconclusive regarding the clinical benefit of pantoprazole sodium delayed-release tablets for symptomatic GERD in the pediatric population.

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PPIs can have severe side effects.

The effective treatment of GERD provides symptom resolution and high rates of remission in erosive esophagitis, lowers the incidence of GERD complications, improves health-related quality of life and reduces the cost of this disease.

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Some medications that decrease stomach acid include cimetidine (Tagamet), ranitidine (Zantac), nizatidine (Axid), and famotidine (Pepcid).

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In addition, the following gastrointestinal problems have been reported in up to 1% of patients (causal relationship is unclear): constipation, dyspepsia, gastroenteritis, nausea, vomiting, anorexia, aphthous stomatitis, cardiospasm, colitis, dry mouth, duodenitis, dysphagia, esophageal hemorrhage, esophagitis, gastrointestinal carcinoma, gastrointestinal hemorrhage, gastrointestinal moniliasis, gingivitis, glossitis, halitosis, hematemesis, increased appetite, increased salivation, melena, mouth ulceration, oral moniliasis, periodontal abscess, periodontitis, rectal hemorrhage, stomach ulcer, tongue discoloration, abnormal stools, hernia, and ulcerative colitis.

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When considering treatment with PPIs, it is important to note that interactions caused by changes in gastric pH are a group-specific effect, but each PPI differs in its propensity to interact with other drugs and the extent to which its interaction profile has been defined.

Furthermore, a meta-analysis that included these trials, along with those for other PPIs, showed no significant differences between high-dose PPI therapy and non-high-dose PPI therapy in rates of rebleeding, surgical intervention, or mortality after endoscopic treatment in patients with PUB.

The information provided on this site should not be used for diagnosing or treating a health problem or disease.

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Pantoprazole was generally safe and well tolerated in children aged 6 through 11 years who were treated with 20 or 40 mg daily for approximately 1 month as well as in adolescents aged 12 through 16 years who were treated with 20 or 40 mg daily for at least 5 consecutive doses.

The quality of evidence, which influences the strength of recommendation, ranges from "high" (further research is very unlikely to change our confidence in the estimate of effect) to "moderate" (further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate) to "low" (further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate), and "very low" (any estimate of effect is very uncertain).

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Clinical outcomes in patients with the concomitant use of clopidogrel and proton pump inhibitors after percutaneous coronary intervention: an analysis from the Guthrie Health Off-Label Stent (GHOST) investigators.

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Pantoprazole also comes in an intravenous (IV) form, which is only given by a healthcare provider.

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